C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/395 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2169459
The retinoblastoma protein (Rb) is the product of the retinoblastoma gene and has been found to contain mutations in retinoblastoma tumor cells. Two nuclear proteins that bind to Rb, p48 and p46 have been isolated and the genes have been cloned. These proteins bind to Rb competitively with the SV40 T antigen. p48 is shown to suppress heat shock sensitive Ras mutations in yeast and is implicated as a modulator of the retinoblastoma suppressor function of Rb.
La protéine du rétinoblastome (Rb) est le produit du gène du rétinoblastome et on a découvert qu'elle contient des mutations dans les cellules tumorales du rétinoblastome. On a isolé deux protéines de noyau p48 et p46, qui se lient à Rb et on a cloné les gènes. Ces protéines se lient de manière compétitive à Rb avec l'antigène SV40 T. On a découvert que p48 supprime les mutations Ras sensibles au choc thermique dans la levure et qu'elle est impliquée comme modulateur de la fonction de suppresion du rétinoblastome de la protéine du rétinoblastome (Rb).
Lee Eva Y.-H.p
Qian Yue-Wei
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Board Of Regents The University Of Texas System
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