C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) G06F 17/50 (2006.01) G06F 19/00 (2006.01)
Patent
CA 2512693
The present invention provides methods for combining computational methods for modulating protein immunogenicity with computational methods for identifying sequences with desired structural and functional properties. More specifically, the methods of the present invention may be used to identify modifications that increase or decrease the immunogenicity of a protein by affecting antigen uptake, MHC binding, T-cell binding, or antibody binding, while retaining or enhancing functional properties.
La présente invention concerne des procédés pour combiner des méthodes de calcul pour moduler le pouvoir immunogène, à des méthodes de calcul pour identifier des séquences ayant des propriétés structurelles et fonctionnelles souhaitées. Plus spécifiquement, les procédés de l'invention peuvent être utilisés pour identifier des modifications qui font augmenter ou diminuer le pouvoir immunogène d'une protéine en agissant sur l'absorption d'antigènes, la liaison CMH, la liaison des lymphocytes T, ou la liaison des anticorps, tout en conservant ou en améliorant les propriétés fonctionnelles.
Chirino Arthur J.
Dahiyat Bassil I.
Desjarlais John Rudolph
Marshall Shannon Alicia
Smart & Biggar
Xencor Inc.
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