C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 231/14 (2006.01) A61K 31/415 (2006.01) A61K 31/4155 (2006.01) A61K 31/4439 (2006.01) A61K 31/454 (2006.01) A61K 31/4545 (2006.01) A61P 25/00 (2006.01) C07D 231/12 (2006.01) C07D 401/06 (2006.01) C07D 401/10 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 409/10 (2006.01)
Patent
CA 2457922
One aspect of the invention is concerned with cannabimimetic pyrazole analogs. Another aspect of the invention is concerned with new and improved pyrazole analogs having high affinities and/or selectivities for the GB 1 cannabinoid receptor. A further aspect of the invention is concerned with pharmaceutical preparations employing the inventive analogs and methods of administering therapeutically effective amounts of the inventive analogs to provide a physiological effect.
L'invention concerne des analogues de pyrazole cannabimim~tiques. L'invention concerne ~galement de nouveaux analogues de pyrazole am~lior~s pr~sentant de hautes affinit~s et/ou s~lectivit~s pour le r~cepteur cannabino~de GB1. L'invention concerne en outre des pr~parations pharmaceutiques dans lesquelles sont utilis~es les analogues de l'invention, ainsi que des m~thodes d'administration de quantit~s efficaces d'un point de vue th~rapeutique des analogues de l'invention afin d'obtenir un effet physiologique.
Liu Qian
Makriyannis Alexandros
Gowling Lafleur Henderson Llp
University Of Connecticut
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