C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 231/14 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01) C07D 231/12 (2006.01) C07D 231/40 (2006.01) C07D 401/02 (2006.01) C07D 401/12 (2006.01) C07D 403/02 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 413/02 (2006.01) C07D 417/02 (2006.01) C07D 453/02 (2006.01) C07D 493/08 (2006.01)
Patent
CA 2098944
The invention relates to compounds of formula: (see fig. I) in which - g2, g3, g4, g5 and g6 and w2, w3, w4, w5 and w6 are identical or different and are independently hydrogen, a chlorine or bromine atom, a (C1-C3)alkyl, a (C1-C3)-alkoxy, a trifluoromethyl or a nitro group and g4 is optionally a phenyl group; - R4 is hydrogen or a (C1-C3)-alkyl; - X is either a direct bond or a group -(CH2)x-N(R3)-, in which R3 is hydrogen or a (C1-C3)-alkyl and x is zero or one; and - R is - a group -NR1R2 in which R1 and R2 are independently a (C1-C6)-alkyl; an optionally-substituted non- aromatic (C3-C15) carbocyclic radical ; an amino (C1-C4) alkyl group in which the amino is optionally disubstituted by a (C1-C3)-alkyl; a cycloalkyl-(C1-C3) alkyl in which the cycloalkyl is C3-C12; a phenyl which is unsubstituted or monosubstituted or polysubstituted by a halogen, by a (C1-C5)-alkyl or by a (C1-C5)-alkoxy; a phenyl (C1-C3)-alkyl; a diphenyl-(C1-C3)- alkyl; a naphthyl; an anthracenyl; a saturated 5- to 8-membered heterocyclic radical which is unsubstituted or substituted by a (C1-C3)- alkyl, by a hydroxyl or by a benzyl group ; a 1-adamantylmethyl an aromatic heterocycle unsubstituted , mono or-polysubstituted by a halogen, a (C1-C5)alkyl, a (C1-C5)-alkoxy or a (C1-C3)-alkyl substituted by an aromatic heterocycle unsubstituted or mono- or - polysubstituted by a halogen, a (C1-C5) alkyl, a (C1-C5)-alkoxy,or else R1 is hydrogen and R2 is as defined above, or else R1 and R2, together with the nitrogen atom to which they are bonded, form a saturated 5- to 8-membered heterocyclic radical, said heterocyclic radical being other than morpholine when w2, w3, w4, w5 and w6 and g2, g3, g4, g5 and g6 are all hydrogen; - a group R2 as defined above when X is -(CH2)x N(R3)-; or - a group R5 when X is a direct bond, R5 being a (C1-C3)-alkyl; a (C3-C12)-cycloalkyl which is unsubstituted or substituted by a (C1-C5)-alkyl; a phenyl-(C1-C3)-alkyl which is unsubstituted or substituted by a halogen or by a (C1-C5)-alkyl; a cycloalkyl-(C1-C3)-alkyl in which the cycloalkyl is C3-C12 and is unsubstituted or substituted by a (C1-C5)-alkyl; or a 2-norbornylmethyl; or one of their salts, where appropriate. These compounds are useful as pharmaceuticals in the therapeutic areas in which cannabis is known to be involved.
Barth Francis
Casellas Pierre
Congy Christian
Martinez Serge
Rinaldi Murielle
Sanofi-Aventis
Sim & Mcburney
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