C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/12 (2006.01) A61K 31/33 (2006.01) A61P 25/06 (2006.01) C07D 213/14 (2006.01) C07D 401/14 (2006.01)
Patent
CA 2707988
Compounds of the formula (I) or a pharmaceutically accept-able salt thereof, wherein, R1 is optionally substituted pyrazolyl, and R2, R3, R4, R5, R6, R7 and R8 are as defined herein. Also disclosed are methods of us- ing the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.
L'invention concerne des composés de formule (I) ou un sel de ceux-ci pharmaceutiquement acceptable, dans laquelle R1 est éventuellement pyrazolyl substitué, et R2, R3, R4, R5, R6, R7 et R8 sont tels que définis dans le descriptif. L'invention concerne également des procédés d'utilisation de ces composés pour le traitement de maladies associées aux antagonistes du récepteur P2X3 et/ou P2X2/3 ainsi que des procédés de fabrication de ces composés.
Chen Li
Dillon Michael Patrick
Feng Lichun
Hawley Ronald Charles
Yang Minmin
Borden Ladner Gervais Llp
F. Hoffmann-La Roche Ag
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