Novel pyrazolo [3,4-d] pyrimidine derivatives as anti-cancer...

Details Novel pyrazolo [3,4-d] pyrimidine derivatives as anti-cancer... Novel pyrazolo [3,4-d] pyrimidine derivatives as anti-cancer...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2711777

The invention relates to substituted pyrazolo [3,4-d] pyrimidine derivatives of the Formula-(I), or pharmaceutically-acceptable salts thereof, which possess anti-proliferative activity such as anti-cancer activity and are accordingly useful in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of substituted pyrazolo [3,4-d] pyrimidine derivatives, to pharmaceutical compositions containing the compound and to its use in the manufacture of medicaments for the production of an anti- proliferative effect in a warm- blooded animal such as man.

La présente invention concerne des dérivés substitutes de pyrazolo [3,4-d] pyrimidine de formule (I), ou leurs sels pharmaceutiquement acceptables, qui possèdent une activité anti-proliférante telle quune activité anticancéreuse et sont donc utiles dans des procédés de traitement de lorganisme humain ou animal. Linvention concerne également des procédés de fabrication de dérivés substitués de pyrazolo [3,4-d] pyrimidine, des compositions pharmaceutiques contenant le composé et son utilisation dans la fabrication de médicaments pour la production dun effet anti-proliférant dans un animal à sang chaud tel quun humain.

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