Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors

Details Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors

A - Human Necessities

61

K

A61K 31/519 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2685278

In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

L'invention concerne, dans de nombreux modes de réalisation, une nouvelle classe de composés de pyrazolo[1,5-a]pyrimidine utilisés comme inhibiteurs des kinases dépendants des cyclines, des méthodes de préparation de ces composés, des compositions contenant au moins un de ces composés, des méthodes de préparation de formulations pharmaceutiques comprenant au moins un de ces composés, et des méthodes utilisant ces composés ou compositions pharmaceutiques pour le traitement, la prévention, l'inhibition ou l'amélioration d'une ou de plusieurs maladies associées aux CDK.

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