Novel pyridazine derivatives, use of the same as...

Details Novel pyridazine derivatives, use of the same as... Novel pyridazine derivatives, use of the same as...

C - Chemistry, Metallurgy

07

D

C07D 237/04 (2006.01) A61K 31/50 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2475439

The invention relates to the products of formula (I) wherein R¿1? represents a hydrogen atom or an optionally substituted alkyl, COR, COOR, aryl, or aralkyl radical; R¿2? represents a radical of formula (II) wherein n is equal to 0, 1, 2 or 3, and X can be a saturated or unsaturated, monocyclic or bicyclic heterocycle radical, an aryl radical, a NR¿4?R¿5? radical, or a COR radical; and R¿3? is a radical of formula -Y-(CH¿2?)¿m?-C(CN)R¿6?R¿7? wherein Y is an oxygen atom or a -N(R¿8?)- radical, and m is equal to 0, 1, 2 or 3. The inventive products are used for the prevention or treatment of diseases with which metabolic enzymes selected from proteases and kinases are associated.

L'invention a pour objet les produits de formule (I): dans laquelle R1 représente un atome d'hydrogène ou un groupement alkyle, COR, COOR, aryle, aralkyle, éventuellement substitué; R2 représente un groupement répondant à la formule (II) suivante : dans laquelle n vaut 0, 1, 2 ou 3; X peut être un groupement hétérocyle monocyclique ou bicyclique saturé ou insaturé; ou un groupement aryle; ou un groupement NR4R5; ou un groupement COR; R3 est un groupement de formule -Y- (CH2)m-C (CN) R6R7, dans laquelle Y est un atome d'oxygène ou un groupement -N(R8)-, m vaut 0, 1, 2 ou 3. Ces produits sont destinés à la prévention ou au traitement de maladies dans lesquelles des enzymes métaboliques choisies parmi les protéases et des kinases sont impliquées.

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