Novel pyridine derivative and medicament containing the same...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 213/69 (2006.01) A61K 31/44 (2006.01) A61K 31/535 (2006.01) A61K 31/55 (2006.01) A61K 31/695 (2006.01) C07D 401/06 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2220231

Pyridine derivatives represented by general formula (1) and salts thereof, and medicines containing the same as the active ingredient, such as a cytokine production inhibitor, wherein R1 and R2 represent each H, alkyl, cycloalkyl, hydroxyalkyl, optionally substituted alkoxyalkyl, carboxyalkyl, alkoxycarbonylalkyl, optionally substituted aralkyl, phenacyl or acyl; R3 represents alkyl, optionally substituted phenyl, heteroaryl or cyclic amino; and X represents O or a combination of OH with H. These compounds have potent and highly specific and safe immune function regulating effects capable of suppressing excessive production of specified cytokines in various immunologic diseases.

Cette invention concerne des dérivés de pyridine, leurs sels, ainsi que des médicaments, tel qu'un inhibiteur de production de cytokine, qui contiennent ces dérivés en qualité d'ingrédient actif. Ces dérivés correspondent à la formule générale (I) où R?1¿ et R?2¿ représentent chacun H, alkyle, cycloalkyle, hydroxyalkyle, alcoxyalkyle éventuellement substitué, carboxyalkyle, alcoxycarbonylalkyle, aralkyle éventuellement substitué, phénacyle ou acyle. R?3¿ représente alkyle, phényle éventuellement substitué, hétéroaryle ou amino cyclique. X représente, quant à lui, O ou une combinaison de OH et de H. Ces composés ont des effets de régulation des fonctions immunologiques puissants, hautement spécifiques et d'une grande sécurité, et sont capables de supprimer la production excessive de cytokines prédéterminées dans diverses affections immunologiques.

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