Novel pyridine derivative and pyrimidine derivative (1)

Details Novel pyridine derivative and pyrimidine derivative (1) Novel pyridine derivative and pyrimidine derivative (1)

C - Chemistry, Metallurgy

07

D

C07D 213/75 (2006.01) A61K 31/4409 (2006.01) A61K 31/4427 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61K 31/4545 (2006.01) A61K 31/496 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) A61K 31/551 (2006.01) A61P 1/18 (2006.01) A61P 9/00 (2006.01) A61P 11/00 (2006.01) A61P 13/08 (2006.01) A61P 13/12 (2006.01) A61P 15/00 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01) A61P 43/00 (2006.01) C07D 239/47 (2006.01) C07D 407/12 (2006.01) C07D 413/12 (

Patent

CA 2543859

A compound represented by the following general formula, a salt thereof, or a hydrate of either. They have excellent inhibitory activity against a hepatocyte growth factor receptor (HGFR) and have antitumor activity, angiogenesis inhibitory activity, or cancer metastasis inhibitory activity. (In the formula, R1 means C1-6 alkyl, etc.; R2 and R3 each means hydrogen; R4, R5, R6, and R7 are the same or different and each means hydrogen, halogeno, C1- 6 alkyl, etc.; R8 means hydrogen, etc.; R9 means C1-6 alkyl, etc.; V1 means oxygen, etc.; V2 means oxygen or sulfur; W means -NH-, etc.; X means -CH=, nitrogen, etc.; and Y means oxygen, etc.)

Un composé représenté par la formule générale suivante, un sel de celui-ci, ou un hydrate d~un de ceux-ci. Ils ont une excellente activité inhibitrice contre un récepteur du facteur de croissance de l~hépatocyte (HGFR) et ont une activité antitumorale, une activité inhibitrice de l~angiogenèse ou une activité inhibitrice des métastases cancéreuses. (I) (Dans la formule, R?1¿ désigne un alkyle en C¿1-6? , etc. ; R?2¿ et R?3¿ désignent chacun de l~hydrogène ; R?4¿, R?5¿, R?6¿, et R?7¿ sont identiques ou différents et chacun désigne de l~hydrogène, de l~halogéno, un alkyle en C¿1-6? , etc. ; R?8¿ désigne de l~hydrogène, etc. ; R?9¿ désigne un alkyle en C¿1-6? , etc. ; V?1¿ désigne de l~oxygène, etc. ; V?2¿ désigne de l~oxygène ou du soufre ; W désigne -NH-, etc. ; X désigne -CH=, de l~azote, etc. ; et Y désigne de l~oxygène, etc.)

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