C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/30 (2006.01) A61K 31/44 (2006.01) C07F 5/02 (2006.01) C07F 7/18 (2006.01)
Patent
CA 2284200
A compound of formula (I) wherein: X is O or S; R1 and R2 are independently hydrogen, C1-6 alkyl or C3-6 cycloakyl or R1 and R2 together with the carbon atom to which they are attached form a C3-6 cycloalkyl group; R3 is hydrogen, and R4 is C1-6 alkyl or C3-6 cycloalkyl or R3 and R4 together with the carbon atom to which they are attached form a C3-6 cycloalkyl group. The compounds of the invention are indicated for use in the treatment or prevention of allergic, inflammatory, auto-immune, proliferative and hyper-proliferative diseases.
L'invention concerne un composé de formule (I) dans laquelle X est O ou S; R?1¿ et R?2¿ sont indépendamment hydrogène, alkyle en C¿1-6? ou cycloalkyle en C¿3-6?, ou R?1¿ et R?2¿ forment avec l'atome de carbone auquel ils sont liés un groupe cycloalkyle en C¿3-6?; R?3¿ est hydrogène, et R?4¿ est alkyle en C¿1-6? ou cycloalkyle en C¿3-6?, ou R?3¿ et R?4¿ forment avec l'atome de carbone auquel ils sont liés un groupe cycloalkyle en C¿3-6?; Les composés de cette invention sont indiqués pour traiter ou prévenir les maladies allergiques, inflammatoires, auto-immunes, prolifératives et hyper prolifératives.
Cheshire David
Cladingboel David
Hirst Simon
Manners Carol
Stocks Michael
Astra Pharmaceuticals Ltd.
Astrazeneca Ab
Fetherstonhaugh & Co.
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