C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/64 (2006.01) A61K 31/4412 (2006.01) A61P 25/00 (2006.01) C07D 401/10 (2006.01) C07D 407/10 (2006.01) C07D 409/10 (2006.01) C07D 413/10 (2006.01)
Patent
CA 2581144
The present invention relates to novel compounds, in particular novel pyridinone derivat ives according to Formula (I) X R1 N Y (I) R2 R3 wherein all radicals are defined in the application. The compounds according to the invention are positive allosteric modulators of metabotropic receptors - subt ype 2 ("mGluR2") which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. In particular, such diseases are central nervous system disorders selected from the group of anxiety, schizophrenia, migraine, depression, and epilepsy. The invention is also directed to pharmaceutical compositions and processes to prepare such compounds and compositions, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR2 is involved.
La présente invention concerne de nouveaux composés, notamment, de nouveaux dérivés de pyridinone de formule (I), dans laquelle tous les radicaux sont tels que définis dans l'application. Les composés de cette invention constituent des modulateurs allostériques positifs de sous-type 2 des récepteurs métabotropiques ("mGluR2") qui sont utilisés dans le traitement ou la prévention de troubles neurologiques et psychiatriques liés à un dysfonctionnement du glutamate et à des maladies, dans lesquelles est impliqué le sous-type mGluR2 des récepteurs métabotropiques. Notamment, de telles maladies constituent des troubles du système nerveux central sélectionnés parmi le groupe comprenant l'anxiété, la schizophrénie, la migraine, la dépression et l'épilepsie. Ladite invention a aussi pour objet des compositions pharmaceutiques et des procédés de préparation de ces composés et compositions, ainsi que leur utilisation dans la prévention et le traitement des maladies, dans lesquelles mGluR2 est impliqué.
Bolea Christelle Martine
Cid-Nunez Jose Maria
Duvey Guillaume Albert Jacques
Finn Terry Patrick
Imogai Hassan Julien
Addex Pharma Sa
Addex Pharmaceuticals S.a.
Janssen Pharmaceutica N.v.
Ortho-Mcneil-Janssen Pharmaceuticals Inc.
Perley-Robertson Hill & Mcdougall Llp
LandOfFree
Novel pyridinone derivatives and their use as positive... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Novel pyridinone derivatives and their use as positive..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel pyridinone derivatives and their use as positive... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1960463