Novel pyrimidine compound having dibenzylamine structure and...

C - Chemistry – Metallurgy – 07 – D

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C07D 239/42 (2006.01) A61K 31/505 (2006.01) A61P 3/06 (2006.01) A61P 7/02 (2006.01) A61P 9/00 (2006.01) A61P 43/00 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2683534

This invention provides a compound represented by general formula (I) having a high level of inhibitory activity against a cholesterol ester transfer protein (CETP) wherein R1, R2, R3, R4, and R5 represent a hydrogen atom, a halo-lower alkyl group, a cyano group or the like; R6 represents an alkyl group, a cycloalkyl group or the like; R7, R8, R9, and R10 represent a hydrogen atom, a halogen atom, a lower alkyl group, a halo-lower alkyl group or the like; R11 and R12 represent a hydrogen atom, a lower alkyl group, a lower cycloalkyl lower alkyl group or the like; and R13 represents a hydrogen atom, a halogen atom, a lower alkoxy group or the like.

L'invention concerne un composé représenté par la formule générale (I) ayant un niveau élevé d'activité inhibitrice contre une protéine de transfert d'ester de cholestérol (CETP) où R1, R2, R3, R4, et R5 représentent un atome d'hydrogène, un groupe halogéno(alkyle inférieur), un groupe cyano ou analogue ; R6 représente un groupe alkyle, un groupe cycloalkyle ou analogue ; R7, R8, R9, et R10 représentent un atome d'hydrogène, un atome d'halogène, un groupe alkyle inférieur, un groupe halogéno(alkyle inférieur) ou analogue ; R11 et R12 représentent un atome d'hydrogène, un groupe alkyle inférieur, un groupe alkyle inférieur de cycloalkyle inférieur, ou analogue ; et R13 représente un atome d'hydrogène, un atome d'halogène, un groupe alcoxy inférieur ou analogue.

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