Novel pyrimidine compounds, process for their preparation...

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 239/28 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) C07D 239/46 (2006.01) C07D 239/48 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01)

Patent

CA 2581454

The present invention provides new heterocyclic compounds, particularly substituted pyrimidines, methods and compositions for making and using these heterocyclic compounds, and methods for treating a variety of diseases and disease states, including atherosclerosis, arthritis, restenosis, diabetic nephropathy, or dyslipidemia, or disease states mediated by the low expression of Perlecan.

L'invention porte: sur de nouveaux composés hétérocycliques et en particulier sur des pyrimidines substituées, sur leurs méthodes et compositions de préparation et d'utilisation, et sur les procédés de traitement de diverses maladies et états morbides dont l'athérosclérose, l'arthrite, les resténoses, la néphropathie diabétique, la dyslipidémie, ou des états morbides médiés par une faible expression de Perlecan.

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