Novel pyrimidineamide derivatives and the use thereof

Details Novel pyrimidineamide derivatives and the use thereof Novel pyrimidineamide derivatives and the use thereof

C - Chemistry, Metallurgy

07

D

C07D 413/14 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2499822

The invention relates to novel substituted N-(3-benzoylaminophenyl)-4-pyridyl- 2-pyrimidinarnine derivatives, processes for the preparation thereof, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of a disease which responds to an inhibition of protein kinase activity, especially a neoplastic disease, and a method for the treatment of such a disease.

L'invention porte sur de nouveaux dérivés de N substitué-(3-benzoylaminophényl)-4-pyridyl-2-pyrimidinamine, sur leurs procédés de préparation, sur les compositions pharmaceutiques les contenant, sur leur utilisation éventuelle en combinaison avec un ou plusieurs autres composés actifs d'un point de vue pharmaceutique, ces nouveaux dérivés étant destinés au traitement d'une maladie qui réagit à une inhibition de l'activité de la protéine kinase, notamment une maladie néoplasique. L'invention porte également sur un procédé de traitement de cette maladie.

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