Novel pyrrhocoricin-derived peptides, and methods of use...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) C07K 7/00 (2006.01) C07K 7/08 (2006.01) C07K 9/00 (2006.01) C07K 14/435 (2006.01) C12N 15/63 (2006.01) C12N 15/82 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2375502

Modifications of the peptide pyrrhocoricin permit the production of a variety of anti-bacterial or anti-fungal peptides having general formula R1-Asp-Lys- Gly-X-Y-Leu-Pro-Arg-Pro-Thr-Pro-Pro-Arg-Pro-Ile-Tyr-X'-Y'-R2[SEQ ID NO:1] or multimeric compositions containing more than a single peptide of that formula. These peptides may be straight chain or cyclic peptides, and may contain one or more non-cleavable bonds. These peptides are characterized by anti- bacterial or anti-fungal activity and metabolic stability in mammalian serum. These peptides are useful in anti-bacterial or anti-fungal pharmaceutical compositions and for further drug development or identification of other antibiotic or anti-fungal compounds.

Des modifications du peptide pyrrhocoricine permettent de produire une variété de peptides antibactériens ou antifongiques représentés par la formule générale R?1¿-Asp-Lys-Gly-X-Y-Leu-Pro-Arg-Thr-Pro-Pro-Arg-Pro-Ile-Tyr-X'-Y'-R?2¿ (SEQ ID NO :1) ou des compositions multimères contenant plus d'un seul peptide de cette formule. Ces peptides peuvent être des peptides de chaîne droite ou des peptides cycliques et contenir une ou plusieurs liaisons non clivables. Ces peptides sont caractérisés par une activité antibactérienne ou antifongique et par une stabilité métabolique dans le sérum mammifère. Ils sont utiles dans des compositions antibactériennes ou antifongiques et peuvent servir avantageusement à développer ou à identifier d'autres composés antibiotiques ou antifongiques.

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