Novel pyrrole derivatives as pharmaceutical agents

Details Novel pyrrole derivatives as pharmaceutical agents Novel pyrrole derivatives as pharmaceutical agents

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/33 (2006.01) A61K 31/41 (2006.01) A61K 31/535 (2006.01) A61P 7/04 (2006.01) A61P 25/28 (2006.01) A61P 31/00 (2006.01) A61P 43/00 (2006.01) C07D 471/04 (2006.01) C07D 498/04 (2006.01)

Patent

CA 2446820

Novel pyrrazole derivative compounds and their use as pharmaceutical agents, in particular their use as TGF-beta signal transduction inhibitors. The disclosed invention relates to compounds of the structure (I) wherein (I) is a four, five, or six membered saturated ring and X is C, O or S.

Cette invention concerne des composés dérivés de pyrrazole et leur utilisation comme agents pharmaceutiques, en particulier comme inhibiteurs de transduction du signal TGF-bêta. Les composés couverts par l'invention sont représentés par la structure (I), qui correspond à un noyau saturé à quatre, cinq ou six éléments et dans laquelle X est C, O ou S.

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