Novel pyrrolinone derivative and pharmaceutical composition...

Details Novel pyrrolinone derivative and pharmaceutical composition... Novel pyrrolinone derivative and pharmaceutical composition...

C - Chemistry, Metallurgy

07

D

C07D 207/38 (2006.01) A61K 31/40 (2006.01) A61K 31/4025 (2006.01) A61K 31/4162 (2006.01) A61K 31/422 (2006.01) A61K 31/427 (2006.01) A61K 31/4439 (2006.01) A61K 31/454 (2006.01) A61K 31/5517 (2006.01) A61P 13/02 (2006.01) A61P 25/02 (2006.01) A61P 25/04 (2006.01) A61P 43/00 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 405/06 (2006.01) C07D 405/10 (2006.01) C07D 409/06 (2006.01) C07D 413/10 (2006.01) C07D 413/14 (2006.01) C07D 417/04 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2682473

A compound represented by the general formula (I): (I) [wherein R1, R2, R3, Z1, Z2, Ra, Rb, q, A, and n are as defined in the description], a pharmaceutically acceptable salt of the compound, or a solvate of either. These are useful as a P2X3 and/or P2X2/3 antagonist.

L'invention porte sur un composé représenté par la formule générale (I) : (I) [dans laquelle R1, R2, R3, Z1, Z2, Ra, Rb, q, A et n sont tels que définis dans la description], sur un sel pharmaceutiquement acceptable du composé, ou sur un solvate de l'un ou l'autre. Ils sont utiles comme antagoniste de P2X3 et/ou P2X2/3.

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