Novel pyrrolo (2,3-b)pyridine derivatives, the preparation...

C - Chemistry – Metallurgy – 07 – D

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C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2558923

The invention relates to novel products of formula (I), wherein R is hydrogen or selected from R2 or R3, R1 is alkenyl or alkyl possibly substituted by CO-NR7R8, -NR7R8, carboxy, hydroxyl, alkoxy or halogen, identical or different R2 and R3 are alkyl or -O-alkyl or possibly substituted by -CO-NR7R8, -NR7R8, alkoxy, alkoxy-NR7R8, carboxy or phenyl, identical or different R4, R5 and R6 are hydrogen, halogen, cyano, amino, alkoxy or alkyl, R4 is also -CH=O, -CH=N-OH and -CH2NHOH, R7 and R8 are, in particular hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, aryl and heteroaryl or R7 and R8 form with an nitrogen atom a possibly substituted heterocycle, said products are embodied in the form of all types of isomers and salts used as drugs.

L'invention concerne les nouveaux produits de formule (I) : dans laquelle R représente hydrogène ou est choisi parmi R2 et R3, R1 représente alkényle ou alkyle éventuellement substitué par -CO-NR7R8, -NR7R8, carboxy, hydroxyle, alcoxy ou halogène, R2 et R3 identiques ou différents représentent alkyle ou - O-alkyle éventuellement substitués par -CO-NR7R8, -NR7R8, alcoxy, alcoxy- NR7R8, carboxy ou phényle, R4, R5 et R6 identiques ou différents représentent hydrogène, halogène, cyano, amino, alcoxy ou alkyle, R4 représentant de plus - CH=O, -CH=N-OH et -CH2NHOH; R7 et R8 représentent notamment hydrogène, alkyle, alkényle, cycloalkyle, cycloalkényle, hétérocycloalkyle, aryle et hétéroaryle ou bien R7 et R8 forment avec l'atome d'azote un hétérocycle éventuellement substitué, ces produits étant sous toutes les formes isomères et les sels, à titre de médicaments.

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