Novel pyrrolo[3,2-d]pyrimidin-4-one derivatives and their...

Details Novel pyrrolo[3,2-d]pyrimidin-4-one derivatives and their... Novel pyrrolo[3,2-d]pyrimidin-4-one derivatives and their...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2591314

There are disclosed novel compounds of formula (I) wherein R1, R12, L, X and Y are as defined in the specification, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme MPO and are thereby particularly useful in the treatment or prophylaxis of neuroinflammatory disorders, cardiovascular disorders and respiratory disorders.

L'invention concerne de nouveaux composés de formule (I). Dans cette formule, R1, R12, L, X et Y sont définis dans la description. L'invention concerne également des sels pharmaceutiquement acceptables de ces composés. L'invention concerne encore des procédés de préparation de ces composés ou de ces sels, des compositions les contenant et leur utilisation dans une thérapie. Les composés de l'invention sont des inhibiteurs de l'enzyme MPO et par conséquent, sont particulièrement utiles dans le traitement ou dans la prophylaxie de troubles neuroinflammatoires, de troubles cardio-vasculaires et de troubles respiratoires.

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