Novel quinoline, tetrahydroquinazoline, and pyrimidine...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 215/42 (2006.01) A61K 31/47 (2006.01) A61K 31/505 (2006.01) A61P 3/04 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01) A61P 43/00 (2006.01) C07D 215/38 (2006.01) C07D 239/28 (2006.01) C07D 239/72 (2006.01)

Patent

CA 2518913

The present invention relates to novel compounds of the Formula (I): which act as MCH receptor antagonists. These compositions are useful in pharmaceutical compositions whose use includes prophylaxis or treatment of improving memory function, sleeping and arousal, anxiety, depression, mood disorders, seizure, obesity, diabetes, appetite and eating disorders, cardiovascular disease, hypertension, dyslipidemia, myocardial infarction, binge eating disorders including bulimia, anorexia, mental disorders including manic depression, schizophrenia, delirium, dementia, stress, cognitive disorders, attention deficit disorder, substance abuse disorders and dyskinesias including Parkinson's disease, epilepsy, and addiction.

La présente invention concerne de nouveaux composés représentés par la formule (I) qui agissent en tant qu'antagonistes du récepteur MCH. Ces compositions sont utiles dans des compositions pharmaceutiques utilisées dans la prophylaxie ou le traitement de la fonction mnésique, du sommeil et du réveil, de l'anxiété, de la dépression, des troubles de l'humeur, des crises, de l'obésité, du diabète, des troubles de l'appétit et de l'alimentation, des maladies cardio-vasculaires, de l'hypertension, de la dyslipidémie, de l'infarctus du myocarde, des troubles de frénésie alimentaire tels que la boulimie, l'anorexie, les troubles mentaux y compris la manie-dépression, la schizophrénie, le délire, la démence, le stress, les troubles cognitifs, le trouble déficitaire de l'attention, les troubles liés à l'abus de substances psychoactives et les dyskinésies y compris la maladie de Parkinson, l'épilepsie et la toxicomanie. Formule (I)

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