Novel quinolonecarboxylic acid derivatives having at...

Details Novel quinolonecarboxylic acid derivatives having at... Novel quinolonecarboxylic acid derivatives having at...

C - Chemistry, Metallurgy

07

D

167/226, 260/277

C07D 401/04 (2006.01) A61K 31/47 (2006.01)

Patent

CA 1340285

Novel compounds of the present invention are represented by the general formula (1) Image wherein R1 is hydrogen atom or amino, R2 is fluorine atom or methoxy, R3 is hydrogen atom or a lower alkyl having 1 to 3 carbon atoms, and n is 0 or 1. The compounds of the general formula (1) exhibit higher antibacterial activity with fewer side-effects than known quinolone antibiotics such as ofloxacin and norfloxacin. Further, the compounds having the general formula (1) have reduced phototoxicity which normally accompanies 6,8-difluoroquinoline antibiotics.

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