C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/46 (2006.01) A61K 39/395 (2006.01) C12N 15/09 (2006.01) C12N 15/13 (2006.01) G01N 33/53 (2006.01) G01N 33/577 (2006.01) C07K 16/22 (2006.01) C07K 16/24 (2006.01) C07K 16/26 (2006.01)
Patent
CA 2688829
The present invention is directed to novel and improved methods for humanizing rabbit heavy and light variable regions. The resulting humanized rabbit heavy and light chains and antibodies and antibody fragments containing are well suited for use in immunotherapy and immunodiagnosis as they retain the antigen binding affinity of the parent antibody and based on their very high level of sequence identity to human antibody sequences should be essentially non-immunogenic in humans. The invention exemplifies the protocol for the manufacture of therapeutic humanized anti-human TNF-alpha and anti-human IL-6 antibodies.
La présente invention concerne de nouveaux procédés améliorés pour l'humanisation de régions variables lourdes et légères de lapin. Les chaînes lourdes et légères de lapin humanisé résultantes et les anticorps et fragments d'anticorps contenants conviennent parfaitement pour une utilisation en immunothérapie et immunodiagnostic puisqu'ils conservent l'affinité de liaison à un antigène de l'anticorps parent et en raison de leur niveau très élevé d'identité de séquence aux séquences d'anticorps humaines ils doivent être essentiellement non immunogènes chez des êtres humains. L'invention donne comme exemple le protocole de fabrication d'anticorps TNF-alpha antihumain et IL-6 antihumain humanisés thérapeutiques.
Kovacevich Brian
Lathan John
Alder Biopharmaceuticals Inc.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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