Novel rapamycin producer

Details Novel rapamycin producer Novel rapamycin producer

C - Chemistry, Metallurgy

12

P

C12P 17/18 (2006.01) C12N 1/20 (2006.01) C12P 19/26 (2006.01)

Patent

CA 2132869

The present invention provides a novel culture which belongs to Actinoplanes (Actinoplanes sp. FERM BP-3832). This culture is capable of producing rapamycin more than ten times efficiently than the cultures which have been reported (e.g., Streptomyces hygroscopicus ATCC 29253). The present invention provides a process for the production of rapamycin which comprises cultivating Actinoplanes sp. FERM BP-3832 and thereafter isolating rapamycin from the fermentation mixture.

L'invention porte sur une nouvelle culture de type Actinoplanes (Actinoplanes sp. FERM BP-3832). Cette culture peut produire la rapamycine avec dix fois plus de rendement que d'autres cultures utilisées antérieurement (p. ex. Streptomyces hygroscopicus ATCC 29253). L'invention présente une méthode pour la production de rapamycine, consistant à cultiver Actinoplanes sp. FERM BP-3832, puis à isoler celle-ci à partir du mélange de fermentation.

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