Novel receptors: their identification, characterization,...

Details Novel receptors: their identification, characterization,... Novel receptors: their identification, characterization,...

C - Chemistry, Metallurgy

12

N

530/13, 195/1.22

C12N 15/16 (2006.01) C07K 14/72 (2006.01) C12N 15/66 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01) G01N 33/74 (2006.01)

Patent

CA 2004339

ABSTRACT OF THE DISCLOSURE Disclosed are novel hormone and hormone-like receptors wherein the trans-activation transcription domain(s) is modified in terms of position and/or copy number or otherwise versus parent receptor, such novel receptors having increased trans-activation transcription activation properties surprisingly superior to the parent receptor. Also disclosed are the recombinant methods and means for preparing such receptors and assays based upon the use of such receptors for screening and identifying putative materials that can affect such receptors and/or for the expression via induced transcription of a reporter or other desired, preferably heterologous gene or DNA product.

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