Novel recombinant adenovirus

Details Novel recombinant adenovirus Novel recombinant adenovirus

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 48/00 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2351314

A recombinant adenovirus containing in its genome: (1) a left terminal inverted repeat sequence; (2) a packaging sequence; (3) a recombinase recognition sequence located between the left-terminal inverted repeat sequence and the packaging sequence; and (4) another recombinase recognition sequence recognized by a recombinase recognizing the above-described recombinase recognition sequence and located downstream of the packaging sequence; which is useful as a material for constructing a vector for gene therapy having a further elevated safety.

L'invention porte sur un adénovirus de recombinaison qui contient dans son génome: (1) une séquence de répétition inversée terminale gauche; (2) une séquence d'encapsidation; (3) une séquence de reconnaissance de recombinase située entre la séquence de répétition inversée terminale gauche et la séquence d'encapsidation et (4) une autre séquence de reconnaissance de recombinase reconnue par une recombinase reconnaissant la séquence de reconnaissance de recombinase présentée ci-avant, et située en aval de la séquence d'encapsidation. Cet adénovirus de recombinaison est utile en tant que matériau de construction d'un vecteur destiné à la thérapie génique possédant un niveau de sécurité élevé.

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