C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/24 (2006.01) A61K 39/395 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2376882
An H chain polypeptide or its fragment of a recombinant antibody against human TNF.alpha. having at least one of the following amino acid sequences: a) as CDR-H1 Gly-Tyr-Thr-Phe-Thr-Asn-Tyr-Gly-Met-Asn; b) as CDR-H2 Trp-Ile-Asn-Thr- Tyr-Thr-Gly-Glu-Pro-Thr-Tyr-Ala-Asp- Asp-Phe-Lys-Gly; and c) as CDR-H3 Tyr-Asp- Tyr-Asp-Gly-Phe-Asp-Tyr; an L chain polypeptide of a recombinant antibody against human TNFa having at least one of the following amino acid sequences: a') as CDR-L1 Thr-Ala-Ser-Ser-Ser-Val-Ser-Phe-Ser-Tyr-Leu-His; b') as CDR-L2 Tyr-Ser-Thr-Ser-Asn-Leu-Ala-Ser; and c') as CDR-L3 His-Gln-Tyr-Leu-Arg-Ser-Pro- Tyr-Thr; and humanized antibodies against human TNF.alpha. or fragments thereof which comprise the above-described H chain polypeptide or its fragment and the above-described L chain polypeptide. Also, a process for producing a humanized anti-TNF.alpha. antibody by transforming host cells with an expression vector having a gene encoding the above antibody, etc. is disclosed.
L'invention concerne un polypeptide à chaîne H ou ses fragments d'un anticorps de recombinaison contre le TNF.alpha. humain, ledit anticorps contenant au moins une des séquences d'acides aminés suivantes ; a) en tant que CDR-H1, Gly-Tyr-Thr-Phe-Thr-Asn-Tyr-Gly-Met-Asn ; b) en tant que CDR-H2, Trp-Ile-Asn-Thr-Tyr-Thr-Gly-Glu-Pro-Thr-Tyr-Ala-Asp-Asp-Phe-Lys-Gly ; et c) en tant que CDR-H3, Tyr-Asp-Tyr-Asp-Gly-Phe-Asp-Tyr. L'invention concerne également un polypeptide à chaîne L d'un anticorps de recombinaison contre le TNF.alpha. humain, ledit anticorps contenant au moins une des séquences d'acides aminés suivantes ; a') en tant que CDR-L1, Thr-Ala-Ser-Ser-Ser-Val-Ser-Phe-Ser-Tyr-Leu-His ; b') en tant que CDR-L2, Tyr-Ser-Thr-Ser-Asn-Leu-Ala-Ser, c') en tant que CDR-L3, His-Gln-Tyr-Leu-Arg-Ser-Pro-Tyr-Thr, ainsi que des anticorps humanisés contre le TNF.alpha. ou des fragments de celui-ci contenant ledit polypeptide à chaîne H ou ses fragments ainsi que ledit polypeptide à chaîne L. L'invention concerne par ailleurs un procédé de production d'anticorps anti-TNF.alpha. humanisé par transformation de cellules hôtes avec un vecteur d'expression contenant un gène codant ledit anticorps, etc.
Fukuda Yoshiaki
Nagahira Kazuhiro
Nakanishi Toshihiro
Daiichi Asubio Pharma Co. Ltd.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Suntory Limited
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