Novel recombinant temperature sensitive mutants of influenza

C - Chemistry – Metallurgy – 12 – N

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C12N 15/54 (2006.01) A61K 39/145 (2006.01) C07K 14/11 (2006.01) C12N 7/01 (2006.01) C12N 7/04 (2006.01) C12N 9/12 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2223579

Recombinant PB2 variant influenza viruses, RNA, cDNA and vectors are provided. Also provided are immunogenic compositions containing the variant viruses, methods of producing such viruses and methods for the prophylactic treatment of influenza in humans.

L'invention concerne des virus de la grippe à variantes PB2 de recombinaison y compris l'ARN, l'ADNc et des vecteurs. L'invention concerne également des compositions immunogéniques qui contiennent lesdits virus à variantes, des procédés permettant de fabriquer ces virus et des procédés utilisables pour le traitement prophylactique de la grippe chez l'homme.

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