Novel resinate complex of s-clopidogrel and production...

Details Novel resinate complex of s-clopidogrel and production... Novel resinate complex of s-clopidogrel and production...

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01)

Patent

CA 2618187

The present invention is a novel resinate complex of (+)-clopidogrel optical isomer, wherein the (+)-clopidogrel isomer is bounded to a water-soluble cation exchange resin having sulfonic acid groups. The novel resinate complex has recognized some advantages in that (1) its chemical structure is stable, and (2) it can be formulated into a solid form that may provide taste-masking capabilities associated with bitter drugs (e.g., strong irritation, bitterness and sour taste), thus requiring no drink of water.

La présente invention concerne un nouveau complexe de résinate d'isomère optique de (+)-clopidogrel, l'isomère de (+)-clopidogrel étant lié à une résine d'échange de cations soluble dans l'eau comprenant des groupes acide sulfonique. Le nouveau complexe de résinate présente les avantages suivants: (1) sa structure chimique est stable; et (2) il peut être formulé sous une forme solide qui peut avoir des capacités de masquage de goût en cas d'association avec des médicaments amers (par ex. forte irritation, amertume et acidité), ce qui permet d'éviter l'ingestion d'eau pour l'absorption.

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