C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 23/00 (2006.01) A61K 31/00 (2006.01) C07C 403/00 (2006.01) C07D 303/14 (2006.01) C07D 303/40 (2006.01) C07F 7/18 (2006.01) C12N 5/02 (2006.01)
Patent
CA 2135298
2135298 9322267 PCTABS00027 The present invention provides a purified retinoid compound characterized by a molecular mass of about 320 daltons and an atomic composition of C20H32O3. The present invention also provides a purified retinoid compound having structure (I), wherein the configuration of the C7, C9, and C11 double bond independently is Z or E and the absolute configuration at C13 and C14 is independently R or S; wherein R1 is alkyl, alkyl halide, alcohol, ester, ether, aldehyde, ketone, carboxylic acid, carboxylic ester, acyl halide, amide, nitrile, or amine; R2 and R3 are independently hydroxyl, halide, alkoxy, ester, alkyl, alcohol, ether, aldehyde, ketone, carboxylic acid, carboxylic ester, nitrile, amine, azide, alkyl halide, acid halide, acid azide, or amide; or wherein R2 and R3, or R1 and R2 are replaced by a 13,14-oxirane or a 14,15-oxirane group, respectively. Also provided by this invention is a pharmaceutical composition which comprises the compound above and a pharmaceutically acceptable carrier. This invention further provides a growth medium comprising the compound above at a concentration effective to enhance cell growth. Additionally, the present invention provides a method of enhancing the growth of a cell, a method for enhancing an immune response in a subject, and a method for enhancing transcription of a gene regulated by retinoid in a cell.
Buck Jochen
Derguini Fadila
Hammerling Ulrich
Nakanishi Koji
Gowling Lafleur Henderson Llp
Sloan Kettering Institute For Cancer Research
The Trustees Of Columbia University
LandOfFree
Novel retinol derivatives and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Novel retinol derivatives and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel retinol derivatives and uses thereof will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1749008