Novel rgs-containing molecules and uses thereof

Details Novel rgs-containing molecules and uses thereof Novel rgs-containing molecules and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) C07H 21/04 (2006.01) C07K 14/47 (2006.01) C07K 16/00 (2006.01) C12N 1/20 (2006.01) C12N 5/10 (2006.01) C12N 9/00 (2006.01) C12P 21/06 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2362239

Novel RGS polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length RGS proteins, the invention further provides isolated RGS fusion proteins, antigenic peptides, and anti-RGS antibodies. The invention also provides RGS nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an RGS gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

L'invention concerne des polypeptides, protéines et molécules d'acides nucléiques RGS de type nouveau. L'invention concerne non seulement des protéines RGS isolées complètes, mais encore des protéines de fusion RGS isolées, des peptides antigéniques et des anticorps anti-RGS. L'invention concerne par ailleurs des molécules d'acides nucléiques RGS, des vecteurs d'expression de recombinaison renfermant une molécule d'acides nucléiques du type décrit dans l'invention, des cellules hôtes dans lesquelles on a introduit les vecteurs d'expression, et des animaux transgéniques non humains dans lesquels on a effectué une introduction ou une disruption de gène RGS. L'invention concerne enfin des procédés diagnostiques, de criblage et thérapeutiques, faisant appel aux compositions visées dans l'invention.

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