Novel salt of morpholine derivative

Details Novel salt of morpholine derivative Novel salt of morpholine derivative

C - Chemistry, Metallurgy

07

D

C07D 265/30 (2006.01)

Patent

CA 2736560

Disclosed is an acid addition salt of (+)-2-[(inden-7-yloxy)methyl]morpholine (compound A), which is intended to be used as a pharmaceutical agent or an active ingredient for a pharmaceutical agent, and has high storage stability, particularly high stability toward humidity and light. Also disclosed is a novel crystal of the acid addition salt. An acid addition salt of compound A with an acid selected from benzenesulfonic acid and hydrobromic acid is a compound which can be isolated in the form of a crystal, takes a solid form at room temperature, exhibits hygroscopicity at such a level that there is no problem for use as a pharmaceutical agent or an active ingredient for a pharmaceutical agent, has stability toward humidity and light, and is therefore extremely useful as a pharmaceutical agent or an active ingredient for a pharmaceutical agent.

La présente invention concerne un sel daddition acide de (+)-2-[(indén-7-yloxy)méthyl]morpholine (composé A), qui est destiné à être utilisé en tant quagent pharmaceutique ou un principe actif pour un agent pharmaceutique, et a une stabilité élevée à la conservation, en particulier une stabilité élevée à lhumidité et la lumière. La présente invention concerne en outre un nouveau cristal du sel daddition acide. Un sel daddition acide de composé A avec un acide choisi parmi lacide benzènesulfonique et lacide bromhydrique est un composé qui peut être isolé sous la forme dun cristal, prend une forme solide à température ambiante, présente une hygroscopicité à un niveau tel quil ny ait pas de problème pour lutilisation en tant quagent pharmaceutique ou principe actif pour un agent pharmaceutique, une stabilité à lhumidité et à la lumière, et est par conséquent extrêmement utile en tant quagent pharmaceutique ou principe actif pour un agent pharmaceutique.

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