Novel salts of metformin and method

Details Novel salts of metformin and method Novel salts of metformin and method

A - Human Necessities

61

K

A61K 31/155 (2006.01) A61P 3/10 (2006.01) C07C 279/26 (2006.01)

Patent

CA 2312990

Novel salts of the antidiabetic agent metformin are provided which are metformin salts of dibasic acids (2:1 molar ratio), preferably metformin (2:1) fumarate and metformin (2:1) succinate, which may be employed alone or in combination with another antihyperglycemic agent such as glyburide, for treating diabetes. A method for treating diabetes employing the novel metformin salt by itself or in combination with another antidiabetic agent is also provided.

L'invention concerne des sels de metformine (antidiabétique), qui sont des sels de diacides (rapport molaire, 2:1). Il s'agit de préférence des fumarate et succinate de metformine (2:1, respectivement), utilisables séparément ou en combinaison avec un autre agent antihyperglycémiant (par exemple, glyburide), pour traiter le diabète. L'invention concerne également un procédé permettant de traiter le diabète au moyens des sels considérés, utilisés séparément ou en combinaison avec un autre antidiabétique.

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