Novel saponin compounds, methods of preparation thereof, use...

Details Novel saponin compounds, methods of preparation thereof, use... Novel saponin compounds, methods of preparation thereof, use...

C - Chemistry, Metallurgy

07

J

C07J 17/00 (2006.01) A61K 31/58 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2751263

This invention relates to novel saponin compounds of formula II wherein MBz denotes p-methoxybenzoyl, and R is selected from the group comprising C6-10 aryl, C6-10 aryl-C1-4 alkyl-, C1- 18 alkanoyl, C3-18 alkenoyl, C6-10 aryl-C(O)-, C6-10 aryl-C1-4 alkyl-C(O)-, wherein each of the groups can optionally be substituted. These compounds possess a selective cytostatic activity, useful, e.g., in the treatment of proliferative diseases. The invention further relates to methods of preparation of the novel com-pounds and to a pharmaceutical composition containing these compounds.

Cette invention concerne de nouveaux composés de saponine de formule II, dans laquelle MBz représente un groupe p-méthoxybenzoyle, et R est choisi dans l'ensemble comprenant les groupes aryle en C6-10, aryle en C6-10-alkyle en C1-4, alcanoyle en C1-18, alcénoyle en C3-18,aryle en C6-10-C(O)-, aryle en C6-10-alkyle en C1-4-C(O)-, tous les groupes pouvant être éventuellement substitués. Ces composés présentent une activité cytostatique sélective, utile, par exemple, dans le traitement de maladies prolifératives. L'invention concerne en outre des procédés de préparation des nouveaux composés et une composition pharmaceutique contenant ces composés.

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