Novel scavenger receptor class a protein

Details Novel scavenger receptor class a protein Novel scavenger receptor class a protein

C - Chemistry, Metallurgy

12

N

C12N 15/09 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12P 21/08 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2441464

A gene and a protein participating in arteriosclerosis caused by foamy macrophages and a method of efficiently evaluating an agent controlling the activity of this protein are provided. A DNA comprising the base sequence represented by SEQ ID NO:1; a scavenger receptor-like protein encoded by this DNA; an antisense nucleic acid to this DNA sequence; and a method of evaluating a substance controlling the activity of the above protein.

L'invention concerne un gène et une protéine impliqués dans l'artériosclérose causée par des macrophages spumeux, ainsi qu'une méthode permettant d'évaluer efficacement un agent régulant l'activité de cette protéine. L'invention concerne également un ADN comprenant la séquence de base représentée par SEQ ID NO:1, une protéine du type récepteur éboueur codée par cet ADN, un acide nucléique antisens destiné à cette séquence d'ADN, ainsi qu'une méthode d'évaluation d'une substance régulant l'activité de la protéine susmentionnée.

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