C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/70 (2006.01) C07K 14/18 (2006.01) C12N 1/15 (2006.01) C12N 9/12 (2006.01) C12P 21/00 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2283379
The invention relates to novel method for identifying antiviral agents which selectively interfere with viral proteins that override interferon-induced cellular defense mechanisms against viral infection. Screening assays are disclosed which identify agents which selectively inhibit the interaction between viral proteins containing an interferon sensitivity determining region, and interferon-induced PKR protein kinase.
L'invention concerne de nouveaux procédés d'identification d'agents antiviraux présentant des interférences sélectives avec des protéines virales neutralisant les mécanismes de défense cellulaire induits par un interféron contre une infection virale. L'invention a pour objet des méthodes de criblage identifiant les agents qui inhibent de manière sélective l'interaction entre des protéines virales comportant une région régissant la sensibilité à l'interféron et la protéine kinase PKR induite par l'interféron.
Gale Michael J. Jr.
Katze Michael G.
Osler Hoskin & Harcourt Llp
University Of Washington
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