C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 45/00 (2006.01) A61P 43/00 (2006.01) C07H 21/04 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01) C12N 15/10 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01) C12P 21/02 (2006.01) C12Q 1/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2328902
Novel secreted and membrane-associated polypeptides, proteins, and nucleic acid molecules are disclosed (e.g., BDSF and STMST molecules). In addition to isolated, full-length proteins, the invention further provides isolated fusion proteins, antigenic peptides and antibodies. The invention also provides nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a BDSF or STMST gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
L'invention porte sur de nouveaux polypeptides, de nouvelles protéines et molécules d'acides nucléique, tous étant sécrétés et associés à une membrane (telles que des molécules BDSF et STMST). Outre les protéines isolées, pleine longueur, l'invention porte également sur des protéines de fusion isolées, des peptides antigéniques et des anticorps. L'invention porte notamment sur des molécules d'acide nucléique, des vecteurs d'expression de recombinaison contenant une molécule d'acide nucléique de l'invention, des cellules hôtes dans lesquelles ont été introduits les vecteurs d'expression, et des animaux transgéniques dans lesquels un gène BDSF ou STMST été introduit ou dissocié. Des procédés de diagnostic, criblage et thérapeutiques utilisant les compositions de cette invention sont également décrits.
Borden Ladner Gervais Llp
Mccarthy Sean A.
Millennium Pharmaceuticals Inc.
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