Novel secreted proteins and polynucleotides encoding them

Details Novel secreted proteins and polynucleotides encoding them Novel secreted proteins and polynucleotides encoding them

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2345377

The present invention provides novel isolated polypeptides chosen from among a) a syncollin-like protein having a syncollin-like activity; b) a novel polypeptide whose amino acid sequence is given by or is similar to SEQ ID NO:6; c) a claudin-like protein having a claudin-like activity; d) a cytokine- like protein whose amino acid sequence has at least 80 % identity to human GRO- beta and having a GRO-beta-like activity, and e) a fragment of any of them; as well as polynucleotides encoding them and antibodies that immunospecifically bind to them. The invention additionally provides several methods in which these proteins, polynucleotides and antibodies are used in methods of detection and methods of treatment are also disclosed. These methods additionally include methods employing proteins, polynucleotides and antibodies related to the additional substances a cysteine-rich soluble protein, and a mammaglobin homologue/endometrial specific steroid-binding factor III. These methods of detection and treatment are directed to a broad range of pathological states.

La présente invention concerne de nouveaux polypeptides isolés choisis parmi a) une protéine de type syncolline ayant une activité de type syncolline; b) un nouveau polypeptide dont la séquence d'acides aminés est donnée par SEQ ID NO:6 ou est similaire à cette séquence; c) une protéine de type claudine ayant une activité de type claudine; d) une protéine de type cytokine dont la séquence d'acides aminés présente au moins une similitude à 80 % avec la protéine GRO-bêta humaine ainsi qu'une activité de type GRO-bêta, et e) un fragment de l'une quelconque des ces protéines ; ainsi que les polynucléotides codant ces protéines et les anticorps qui lient immunospécifiquement ces protéines. L'invention concerne également plusieurs techniques utilisant ces protéines, polynucléotides et anticorps dans le cadre de méthodes de détection et de traitement. Ces techniques comprennent, en outre, des méthodes utilisant des protéines, des polynucléotides et des anticorps associés aux substances supplémentaires d'une protéine soluble riche en cystéine et d'un homologue de mammaglobine/ facteur III de liaison des stéroïdes spécifique à l'endomètre. Ces techniques sont destinées à la détection et au traitement d'une large gamme d'états pathologiques.

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