Novel secretory leader sequences for yeasts

Details Novel secretory leader sequences for yeasts Novel secretory leader sequences for yeasts

C - Chemistry, Metallurgy

07

K

530/7.1, 530/15.

C07K 14/39 (2006.01) C07K 14/765 (2006.01) C07K 19/00 (2006.01) C12N 1/19 (2006.01) C12N 15/14 (2006.01) C12N 15/31 (2006.01) C12N 15/62 (2006.01) C12N 15/81 (2006.01) C12P 21/02 (2006.01)

Patent

CA 1340547

Secretory leader sequences, for use in secreting heterologous polypeptides in yeast, are formed by fusing part of the human serum albumin pre-sequence or part of the Kluyveromyces lactis killer toxin pre-sequence to the Saccharomyces cerevisiae mating factor alpha-1 KEX2 cleavage recognition site. The resulting fusion leader sequences are: (a) H2N-Met-Lys-Trp-Val-Ser-Phe-Ile-Ser-Leu-Leu-Phe-Leu- Phe-Ser-Ser-Ala-Tyr-Ser-Arg-Ser-Leu-Asp-Lys-Arg-COOH or (b) H2N-Met-Asn-Ile-Phe-Tyr-Ile-Phe-Leu-Phe-Leu-Leu-Ser- Phe-Val-Gln-Gly-Ser-Leu-Asp-Lys-Arg-COOH Conservative variations are also encompassed.

605832

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