Novel seh inhibitors and their use

Details Novel seh inhibitors and their use Novel seh inhibitors and their use

C - Chemistry, Metallurgy

07

D

C07D 251/18 (2006.01) A61K 31/53 (2006.01) A61P 3/10 (2006.01) A61P 9/12 (2006.01) A61P 11/00 (2006.01) C07D 401/04 (2006.01) C07D 409/04 (2006.01)

Patent

CA 2702265

The invention is directed to novel sEH inhibitors and their use in the treatment of diseases mediated by the sEH enzyme. Specifically, the invention is directed to compounds according to Formula I wherein R1, R2, R4, R5, R6, A, B, Y, Z, n, and m are defined below, and to pharmaceutically-acceptable salts thereof. The compounds of the invention are sEH inhibitors and can be used in the treatment of diseases mediated by the sEH enzyme, such as hypertension. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting sEH and treatment of conditions associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

La présente invention concerne de nouveaux inhibiteurs de sEH et leur utilisation dans le traitement de maladies médiées par l'enzyme sEH. De façon spécifique, l'invention concerne des composés répondant à la formule I : R1, R2, R5, R6, A, B, Y, Z, n, et m étant définis ci-après, et des sels pharmaceutiquement acceptables de ces composés. Les composés de l'invention sont des inhibiteurs de sEH et peuvent être utilisés dans le traitement de maladies médiées par l'enzyme sEH, telles que l'hypertension. Par conséquent, l'invention concerne également des compositions pharmaceutiques contenant un composé de l'invention. L'invention concerne de plus des procédés d'inhibition de sEH et le traitement de pathologies y étant associées au moyen d'un composé de l'invention ou d'une composition pharmaceutique contenant un composé de l'invention.

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