Novel semaphorin gene: semaphorin w

Details Novel semaphorin gene: semaphorin w Novel semaphorin gene: semaphorin w

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12P 21/08 (2006.01) G01N 33/48 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2268006

Semaphorin W having an inhibitory effect on nerve extension and its gene; other semaphorins hybridizable with the semaphorin W gene; modified proteins and partial peptides of the semaphorin W; an antibody against the semaphorin W; an antisense nucleotide of the semaphorin W gene; the use of these substances as medicines, diagnostic drugs or research reagents; a method for screening semaphorin W antagonists with the use of the semaphorin W; semaphorin W antagonists obtained by this screening method; medicines containing these antagonists; and transgenic animals, etc. relative to the semaphorin W.

L'invention concerne la sémaphorine W ayant un effet inhibiteur sur l'extension nerveuse et son gène; d'autres sémaphorines pouvant s'hybrider avec le gène de la sémaphorine W; des protéines modifiées et des peptides partiels de la sémaphorine W; un anticorps dirigé contre la sémaphorine W; un nucléotide antisens du gène de la sémaphorine W; l'utilisation de ces substances en tant que médicaments, que substances de diagnostic ou réactifs de recherche; un procédé de recherche d'antagonistes de la sémaphorine W à l'aide de la sémaphorine W; des antagonistes de la sémaphorine W produits par cette méthode de recherche; des médicaments contenant ces antagonistes et, entre autres, des animaux transgéniques, etc. en rapport avec la sémaphorine W.

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