Novel semaphorin gene: semaphorin y

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 14/475 (2006.01) C07K 16/18 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2265500

The present invention provides Semaphorin Y inhibiting neurite outgrowth, and a gene therefor, as well as other Semaphorins hybridizing to said Semaphorin Y gene, modified proteins or partial peptides of said Semaphorin Y, antibodies against said Semaphorin Y, antisense nucleotides against said Semaphorin Y gene, and the use of such substances as pharmaceutical or diagnostic agents or laboratory reagents. The present invention further provides a method of screening for Semaphorin Y antagonists employing said Semaphorin Y, Semaphorin Y antagonists obtained by said screening method, pharmaceutical agents comprising such antagonists, and transgenic animals involving said Semaphorin Y.

L'invention concerne la sémaphorine Y présentant un effet inhibiteur sur les prolongements nerveux, son gène, une autre sémaphorine hybridable avec le gène de la sémaphorine Y, des protéines modifiées et des peptides partiels de la sémaphorine Y, un anticorps contre la sémaphorine Y, le nucléotide antisens du gène de la sémaphorine Y, les utilisations de ces substances en tant que médicaments, agents diagnostiques ou réactifs expérimentaux, un procédé de criblage d'antagonistes de la sémaphorine Y à l'aide de la sémaphorine Y, les antagonistes de la sémaphorine Y obtenus selon ce procédé de criblage, des médicaments contenant ces antagonistes et des animaux transgéniques liés à la sémaphorine Y.

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