C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/57 (2006.01) A61K 45/00 (2006.01) A61P 1/00 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/00 (2006.01) C12N 9/64 (2006.01) C12Q 1/37 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2494793
It is intended to disclose a novel polypeptide which is useful in searching for a remedy for a specific disease in which a digestive hormone participates (in particular, irritable bowel syndrome); a polynucleotide encoding the above polypeptide; an expression vector containing the above polynucleotide; and cells transfected with the above expression vector. The polypeptide as described above is a novel type II transmembrane serine protease or its derivative participating in the control of a hormone produced in the digestive tract. It is also intended to disclose a method of screening a remedy for a digestive disease with the use of the above polypeptide; and a process for producing a medicinal composition for treating a digestive disease which contains as the active ingredient a substance obtained by the above-described screening method.
L'invention concerne un polypeptide utile dans la recherche d'un remède concernant une maladie spécifique dans laquelle participe une hormone de la digestion (en particulier, syndrome de l'intestin irritable), un polynucléotide codant pour ce polypeptide, une vecteur d'expression contenant ce polynucléotide, et des cellules transfectées par ce vecteur d'expression. Le polypeptide décrit est une sérine protéase transmembranaire de type II, ou un de ses dérivés, participant au contrôle d'une hormone produite dans le tractus digestif. L'invention concerne aussi un procédé de criblage d'un remède destiné à une maladie de la digestion, au moyen de ce polypeptide, ainsi qu'un procédé de production d'une composition médicale, traitant une maladie de la digestion, contenant en tant que principe actif une substance obtenue au moyen du procédé de criblage décrit.
Takeda Masayoshi
Yamaji Noboru
Astellas Pharma Inc.
Dennison Associates
Yamanouchi Pharmaceutical Co. Ltd.
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