Novel serine protease inhibitors: derivatives of...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 275/03 (2006.01) A61K 31/425 (2006.01) A61K 31/675 (2006.01) C07D 275/06 (2006.01) C07D 285/10 (2006.01) C07D 417/06 (2006.01) C07D 521/00 (2006.01) C07F 9/6539 (2006.01)

Patent

CA 2179913

Isothiazolidin-3-one-1,1 dioxide,3-oxo-1,2,5-thiadiazolidine-1,1-dioxide and derivatives thereof, reduce or inhibit the activity of serine proteases. Such compounds are useful as anti-inflammatory and anti-metastatic agents.

Cette invention se rapporte aux composés isothiazolidin-3-one-1,1 dioxyde et 3-oxo-1,2,5-thiadiazolidine-1,1-dioxyde, ainsi qu'a des dérvivés de ces composés, qui servent à réduire ou à inhiber l'activité des sérine-protéases. Ces composés sont utiles comme agents anti-inflammatoires et antimétastatiques.

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