C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/15 (2006.01) C07H 21/04 (2006.01) C07K 14/81 (2006.01) C07K 16/38 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2223086
The present invention provides nucleotide and amino acid sequences that identify and encode a novel serpin (CAPE) expressed in human hypothalamus. The present invention also provides for antisense molecules to the nucleotide sequences which encode CAPE, expression vectors for the production of purified CAPE, antibodies capable for binding specifically to CAPE, hybridization probes or oligonucleotides for the detection of CAPE-encoding nucleotide sequences, genetically engineered host cells for the expression of CAPE, a pharmaceutical composition containing biologically active CAPE, a diagnostic test based on CAPE-encoding nucleic acid molecules, and treatment methods comprising administration of biologically active CAPE.
L'invention concerne des séquences de nucléotides et d'aminoacides qui identifient et codent une nouvelle serpine (CAPE) exprimée dans l'hypothalamus humain. L'invention concerne également des molécules antisens par rapport aux séquences de nucléotides qui code la CAPE, des vecteurs d'expression pour la préparation de CAPE purifiée, des anticorps aptes à se lier de manière spécifique à la CAPE, des sondes d'hybridation ou des oligonucléotides servant à détecter des séquences de nucléotides codant la CAPE, des cellules hôtes produites par génie génétique et servant à exprimer la CAPE, une composition pharmaceutique contenant de la CAPE biologiquement active, un test diagnostique à base de molécules d'acide nucléique codant la CAPE, ainsi que des méthodes de traitement comprenant l'administration de CAPE biologiquement active.
Braxton Scott Michael
Diep Dinh
Stuart Susan G.
Incyte Genomics Inc.
Incyte Pharmaceuticals Inc.
Smart & Biggar
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