C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/713 (2006.01) A61K 39/395 (2006.01) C07H 21/02 (2006.01) C12N 15/63 (2006.01) A61K 48/00 (2006.01) C12N 15/12 (2006.01)
Patent
CA 2666270
The invention relates to compounds, in particular siRNAs, which inhibit the expression of specific human genes. The invention also relates to pharmaceutical compositions comprising such compounds and a pharmaceutically acceptable carrier. The present invention also provides a method of treating and/or preventing the incidence or severity of various diseases or conditions associated with the genes and/or symptoms associated with such diseases or conditions comprising administering to a subject in need of treatment for such disease or condition and/or symptom the compound or the pharmaceutical composition in a therapeutically effective dose so as to thereby treat the subject. The invention also provides antibodies which inhibit specified human polypeptides and pharmaceutical compositions comprising one or more such antibodies.
L'invention concerne des composés, en particulier les ARNsi, qui inhibent l'expression de gènes humains spécifiques. L'invention concerne également des compositions pharmaceutiques comprenant de tels composés et un support pharmaceutiquement acceptable. La présente invention concerne également un procédé de traitement et/ou de prévention de l'incidence ou de la gravité de diverses maladies ou états associés aux gènes et/ou symptômes associés à de telles maladies ou états comprenant l'administration à un sujet qui a besoin d'un traitement pour une telle maladie ou un tel état et/ou symptôme, du composé ou de la composition pharmaceutique dans une dose thérapeutiquement efficace de façon à traiter de ce fait le sujet. L'invention se rapporte également à des anticorps qui inhibent des polypeptides humains spécifiés et à des compositions pharmaceutiques qui comprennent ledit ou lesdits anticorps.
Feinstein Elena
Idelson Gregory Hirsh
Kalinski Hagar
Mett Igor
Skaliter Rami
Quark Pharmaceuticals Inc.
Sim & Mcburney
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