Novel solubility enhancer and use thereof

Details Novel solubility enhancer and use thereof Novel solubility enhancer and use thereof

A - Human Necessities

61

K

A61K 31/16 (2006.01)

Patent

CA 2623296

Disclosed herein is a novel solubility enhancer capable of being employed in formulating safe and effective pharmaceutical formulations of partially soluble drugs, wherein the solubility enhancer is selected from dialkyl substituted amides of fatty acids having C6 to C16 carbon chain, preferably from N,N-dimethyl hexanamide,N,N- dimethyl octanamide, N,N-dialkyl decanamide, N,N-dialkyl dodecanamide or N,N- dialkyl hexadecanamide.

L'invention concerne un nouvel activateur de solubilité pouvant être employé pour la préparation de formulations pharmaceutiques sûres et efficaces de médicaments partiellement solubles. Cet activateur de solubilité est sélectionné dans le groupe constitué par des amides substitués par dialkyle d'acides gras présentant une chaîne carbone C6 à C16, de préférence dans le groupe constitué par N,N-diméthyl-hexanamide, N,N-diméthyl-octanamide, N,N-dialkyl-décanamide, N,N-dialkyl-dodécanamide ou N,N-dialkyl-hexadecanamide.

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