Novel soluble cd83 polypeptides, formulations and methods of...

C - Chemistry – Metallurgy – 07 – K

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C07K 14/705 (2006.01) A61K 38/17 (2006.01) A61P 37/06 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2725198

Compositions and methods for treating or preventing unwanted immune responses are provided. The compositions relate to novel soluble CD83 (sCD83) polypeptides and nucleic acids encoding such polypeptides, improved (sCD83) formulations, and the use of such polypeptides and formulations in the treatment or prevention of allergy, autoimmune disease and transplant rejection. A sCD83 polypeptide is provided, comprising SEQ ID NO:7 or an amino acid sequence having at least 70% identity to SEQ ID NO:7; wherein one or more of amino acid residues 12, 20, 85 and 92 of SEQ ID NO:7 is an amino acid other than cysteine; and optionally, one or more of amino acid residues 1, 2, 3, 4 and 130 are absent.

La présente invention concerne des compositions et des procédés permettant de traiter ou de prévenir l'apparition de réponses immunitaires non souhaitées. L'invention concerne donc des polypeptides CD83 solubles (sCD83) inédits et des acides nucléiques codant pour lesdits polypeptides, des formulations améliorées et l'utilisation de ces polypeptides et formulations dans le traitement ou la prévention de l'allergie, des maladies auto-immunes et du rejet des greffes. L'invention concerne un polypeptide sCD83, comprenant SEQ ID NO : 7 ou une séquence d'acides aminés présentant au moins 70 % d'identité avec SEQ ID NO : 7, dans laquelle un ou plusieurs des résidus d'acides aminés 12, 20, 85 et 92 de SEQ ID NO : 7 sont des acides aminés autres que la cystéine ; et dans laquelle éventuellement, un ou plusieurs des résidus d'acides aminés 1, 2, 3, 4 et 130 sont absents.

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