C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) G01N 33/566 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2601668
The invention relates to a novel soluble form of EPCR originating from an alternative splicing mechanism and, more specifically, to a polypeptide comprising residues 201-256 of sequence SEQ ID NO: 1 or a fragment of said sequence. The invention also relates to a recombinant or isolated EPCR protein comprising said polypeptide, an isolated polynucleotide that codes for said polypeptide, an mRNA encoding a protein that comprises said polypeptide and to the use thereof in the detection of diseases. The invention further relates to an expression vector or a host cell comprising said polynucleotide, an expression system that comprises the expression vector and said cell, a specific isolated antibody for said polypeptide, and a method and a kit for the selective in vitro detection in a biological sample of an EPCR protein comprising sequence SEQ ID NO: 1.
L'invention concerne une nouvelle forme soluble de EPCR provenant d'une variante d'un mécanisme de coupe-épissure, et d'une manière plus spécifique, un polypeptide qui comprend les résidus 201-256 de la séquence SEQ ID NO: 1 ou un fragment de cette séquence, ainsi qu'une protéine EPCR isolée ou recombinée qui comprend ledit polypeptide, un polynucléotide isolé qui code pour ledit polypeptide, un ARNm qui code pour une protéine comprenant ledit polypeptide et son utilisation dans la détection de maladies, un vecteur d'expression ou une cellule hôte qui comprend ledit polynucléotide, lequel comprend un système d'expression comprenant le vecteur d'expression et ladite cellule, un anticorps isolé spécifique dudit polypeptide, une méthode et une trousse de détection sélective in vitro dans un échantillon biologique, d'une protéine EPCR qui comprend la séquence SEQ ID NO: 1.
Hermida Santos Jose
Martinez Anso Eduardo
Molina Buey Eva
Montes Diaz Ramon
Marks & Clerk
Proyecto de Biomedicina Cima S.l.
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