C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/10 (2006.01) A61K 31/40 (2006.01) A61K 31/47 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01) G01N 33/94 (2006.01)
Patent
CA 2546147
The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nACh receptors), activation of nACh receptors, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (e.g., indazoles and benzothiazoles) which act as ligands for the .alpha.7 nACh receptor subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof. Formulas (I, II, III, IV).
L'invention concerne des composés de formule (I) et des sels acceptables pharmaceutiquement, des solvates et des stéréo-isomères associés. Dans la formule (I), A, B, E, G, W, X, Y, Z, o, et R1 sont tels que spécifiés dans l'invention (<= composés de l'invention), et sont utilisés en tant qu'agents cardioprotecteurs et/ou neuroprotecteurs. Cette invention a aussi trait à des compositions pharmaceutiques renfermant un composé de l'invention et à des méthodes de traitement, de prévention et/ou de gestion d'une maladie ou d'un trouble vasculaire, cardio-vasculaire ou neurologique, lesdites méthodes consistant à administrer à un patient le nécessitant un composé de l'invention.
Adams John W.
Babych Eric D.
Boatman P. Douglas
Moody Jeanne V.
Schrader Thomas O.
Arena Pharmaceuticals Inc.
Smart & Biggar
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